Product Name :
Osteoprotegerin Rabbit Polyclonal Antibody
Predicted band size :
46 kDa
Observed band size :
55 kDa
Synonyms:
MGC29565 antibody OCIF antibody OPG antibody Osteoclastogenesis inhibitory factor antibody Osteoprotegerin antibody PDB5 antibody TNF receptor superfamily member 11b antibody TNFRSF 11B antibody TNFRSF11B antibody TR 1 antibody 展开
Function :
Bone morphogenesis and remodeling involve the formation of bone from osteoblasts and the resorption of bone by osteoclasts. The cytokine osteoprotegerin (OPG), also designated osteoclastogenesis inhibitory factor (OCIF), is known to inhibit osteoclast formation. A secreted glycoprotein, OPG is a member of the TNF receptor family that increases bone density and volume. OPG is thought to inhibit osteoclastogenesis by disrupting the cell-to-cell signaling between osteoblastic stromal cells and osteoclast progenitors. OPG is known to bind to TRAIL, a death domain-containing protein, and to inhibit TRAIL apoptosis in Jurkat cells. OPG also binds to osteoclast differentiation factor (ODF), also known as TRANCE/RANKL, a membrane-bound protein belonging to the TNF ligand family. Both TNFα and TNFβ upregulate OPG expression, while the bone resorbing agent prostaglandin E2 downregulates OPG.
Antibody Type:
Rabbit Polyclonal Antibody
Immunogen :
Recombinant protein within Human Osteoprotegerin aa 1-222 / 401.
Species reactivity:
Human, Mouse, Rat
Verify application:
WB, IF-Cell, IHC-P, FC
Coupling :
unconjugated
Clone number:
RRID:
AB_3073414
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing.2-Ethynylpyrazine Formula Aliquot store at -20℃ or -80℃.Price of N3-PEG3-C2-NHS ester Avoid repeated freeze / thaw cycles.PMID:33668068
Storage buffer solution:
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
46 kDa
Positive control :
293 cell lysate, K562 cell lysate, K-562, Neuro-2a, C6, human lung cancer tissue, human breast cancer tissue, human kidney tissue, mouse kidney tissue, mouse brain tissue.