Product Name :
PON1 Recombinant Rabbit Monoclonal Antibody [JE30-90]
Predicted band size :
40 kDa
Observed band size :
40 kDa
Synonyms:
A esterase 1 antibody A-esterase 1 antibody Aromatic esterase 1 antibody Arylesterase 1 antibody Arylesterase B type antibody ESA antibody Esterase A antibody K 45 antibody K-45 antibody MVCD5 antibody 展开
Function :
PON1 is responsible for hydrolysing organophosphate pesticides and nerve gasses. Polymorphisms in the PON1 gene significantly affect the catalytic ability of the enzyme. PON1 (paraoxonase 1) is also a major anti-atherosclerotic component of high-density lipoprotein (HDL). The PON1 gene is activated by PPAR-γ, which increases synthesis and release of paraoxonase 1 enzyme from the liver, reducing atherosclerosis. The “natural” substrates for PON1 appear to be lactones. However, PON1 has evolved to be a highly promiscuous enzyme capable of hydrolysing a wide variety of substrates such as lactones (including a number of important pharmaceutical agents such as statins), glucuronide drugs, thiolactones, arylesters, cyclic carbonates, organophosphorus pesticides and nerve gases such as sarin, soman and VX, oestrogen esters and lipid peroxides (oxidised lipids).Formula of 1269440-73-4
Antibody Type:
Recombinant Rabbit monoclonal Antibody
Immunogen :
Synthetic peptide within Human PON1 aa 101-150 / 355.Benzofuran-4-carboxylic acid Purity
Species reactivity:
Human, Mouse, Rat
Verify application:
WB, IHC-P, FC
Coupling :
unconjugated
Clone number:
JE30-90
RRID:
AB_3072498
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing.PMID:33583328 Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
Storage buffer solution:
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 40 kDa
Positive control :
Human liver tissue lysate, mouse liver tissue lysate, rat liver tissue lysate, human liver carcinoma tissue, human liver tissue, mouse liver tissue, rat liver tissue, HepG2.