Product Name :
Phospho-PKC delta (Y311) Recombinant Rabbit Monoclonal Antibody [JE44-20]
Predicted band size :
78 kDa
Observed band size :
78 kDa
Synonyms:
CVID9 antibody D14Ertd420e antibody Kinase PKC delta antibody KPCD antibody KPCD_HUMAN antibody MAY 1 antibody MAY1 antibody MGC49908 antibody nPKC delta antibody nPKC-delta antibody 展开
Function :
Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression as well as survival of several cancers, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses. Negatively regulates B cell proliferation and also has an important function in self-antigen induced B cell tolerance induction (By similarity).BuyPyrazine-2,3-diamine Upon DNA damage, activates the promoter of the death-promoting transcription factor BCLAF1/Btf to trigger BCLAF1-mediated p53/TP53 gene transcription and apoptosis.Bis(cyclooctadiene)dichlorodirhodium Chemscene In response to oxidative stress, interact with and activate CHUK/IKKA in the nucleus, causing the phosphorylation of p53/TP53. In the case of ER stress or DNA damage-induced apoptosis, can form a complex with the tyrosine-protein kinase ABL1 which trigger apoptosis independently of p53/TP53.
Antibody Type:
Recombinant Rabbit monoclonal Antibody
Immunogen :
Synthetic phosphopeptide corresponding to residues surrounding Tyr311 of human PKC delta.
Species reactivity:
Human, Mouse, Rat
Verify application:
WB
Coupling :
unconjugated
Clone number:
JE44-20
RRID:
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing.PMID:33731806 Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
Storage buffer solution:
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 78 kDa
Positive control :
THP-1 cell lysate, THP-1 treated with 50ng/mL PMA for 72 hours cell lysate, THP-1 treated with 100ng/mL PMA for 72 hours cell lysate, mouse small intestine tissue lysate, rat lung tissue lysate.