Product Name :
SESN1 Recombinant Rabbit Monoclonal Antibody [JE36-66]
Predicted band size :
57 kDa
Observed band size :
70 kDa
Synonyms:
1110002G11Rik antibody AU044290 antibody MGC118148 antibody MGC138241 antibody MGC142129 antibody OTTMUSP00000022799 antibody p53 activated gene 26 antibody p53 regulated PA26 nuclear protein antibody p53 regulated protein PA26 antibody p53-regulated protein PA26 antibody 展开
Function :
Sestrin 1, also known as p53-regulated protein PA26, is a protein that in humans is encoded by the SESN1 gene. This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Antibody Type:
Recombinant Rabbit monoclonal Antibody
Immunogen :
Synthetic peptide within Human SESN1 aa 100-200.
Species reactivity:
Human
Verify application:
WB, IF-Cell, IHC-P, FC
Coupling :
unconjugated
Clone number:
JE36-66
RRID:
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing.Formula of 2-Bromo-4,5-difluoropyridine Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
Storage buffer solution:
1*TBS (pH7.Buy(4-Chloropyridin-2-yl)methanamine 4), 0.PMID:33593265 05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 57 kDa
Positive control :
HeLa cell lysate, K-562 cell lysate, Ramos cell lysate, K-562, human breast cancer tissue, mouse heart tissue.