Ight ameliorate insulin resistance by modulating important molecules inside the insulin signaling pathway, major to enhanced glucose uptake in insulin-resistant cells [25]. Hence, we suspect that these components could possibly explain the role of FTZ in ameliorating insulin resistance.Conclusion In conclusion, our study indicated that FTZ could reduce serum triglyceride, total cholesterol and fasting blood glucose and enhance serum HDL-C, thereby reactivating the insulin-stimulated IRS1/PI3K pathway in insulin-resistant HepG2 cells and up-regulating PI3K expression in adipose tissue. As a result, the effective effects of FTZ on insulin resistance recommend that this decoction could be a promising therapeutic for MS and insulin resistance.Abbreviations FTZ: Fu Fang Zhen Zhu Tiao Zhi formula; MS: Metabolic syndrome; IR: Insulin resistance; IRS1: Insulin receptor substrate-1; PI3K: Phosphatidylinositol 3-kinase; TG: Triglyceride; TC: Total cholesterol; HDL-C: HDL-cholesterol; FPG: Fasting plasma glucose; FPI: Fasting plasma insulin; HOMA-IR: Homeostasis model assessment- insulin resistance index. Competing interests The author(s) declare that they’ve no competing interests. Authors’ contributions Dr. J.Guo and Xuguang Hu developed the study. Man Wang carried out experiments. Bei WJ and Wang LY, participated inside the design and style of study, interpretation of outcomes, and drafted the manuscript. Mr. Shuyan Li, Zongyu Han, Xiuteng Zhou, Le Cao, Hu Yinming, Ms. Wei He, Junhui Peng and Duosheng Luo have took part in the study projects. All authors have read and approved the final manuscript.Hu et al. Journal of Translational Medicine 2014, 12:47 http://translational-medicine/content/12/1/Page 8 ofAcknowledgements This study was supported by grants in the All-natural Sciences Funds, Republic of China (nos.81173626,2011), Guangdong Province-Chinese Education Ministry Market, Education and Study Cooperation Project (no. 2011B090400379), Guangdong Province Natural Sciences Funds Investigation Group Project(no. 10351022401000000). Received: 7 December 2013 Accepted: 17 February 2014 Published: 20 FebruaryReferences 1. Reaven GM: Part of insulin resistance in human disease. Diabetes 1988, 37:1595?607. 2. Zimmet PZ, McCarty DJ: The global epidemiology of non-insulin-dependent diabetes mellitus and also the metabolic syndrome. J Diabetes Complications 1997, 11:60?8. 3. Guo J: A drug for the remedy of hyperlipidemia[P]. China; 2004. 0410051250.4. four. Cao Y, Bei W, Hu Y, Cao L, Huang L, Wang L, Luo D, Chen Y, Yao X, He W, Liu X, Guo J: Hypocholesterolemia of Rhizoma Coptidis alkaloids is associated for the bile acid by up-regulated CYP7A1 in hyperlipidemic rats.1196154-13-8 manufacturer Phytomedicine 2012, 19:686?92.3-Cyclopropyl-1H-1,2,4-triazole manufacturer five.PMID:33751641 Tong G, Jiao G, Wei H: The clinical observation of Fufang Zhenshu Tiaozhi on hyperlipemia. Journal of Shandong University of TCM 2006, 30:204?06. 6. Guo J, Bei WJ, Tang CP: The impact of Fufang Zhenshu Tiaozhi extract on hepatic lipase in diet-induced hyperlipidemic rats. Zhong Yao Cai 2009, 32:582?85. 7. Tong G, Jiao G, Yingyu L: The effect of Fufang Zhenshu Tiaozhi around the viscosity of plasma and entire blood in hyperlipidemic patients. Journal of Practical regular Chinese medicine 2006, 22(ten):608?09. eight. Wu HY, Bei WJ, Guo J: Chinese herbal medicine for the remedy of dyslipidemia. J Geriatr Cardiol 2009, 6:119?25. 9. Guo J, Bei WJ, Hu YM, Tang CP, He W, Liu XB, Huang LH, Cao Y, Hu XG, Zhong XL, Cao L: A new TCM formula FTZ lowers serum cholesterol by regulating HMG-CoA reductase an.