Product Name :
2-Chloroadenosine (CAS 146-77-0)
Synonym :
2-CADO
Application :
2-Chloroadenosine is an Adenosine A receptor agonist
CAS:
146-77-0
Purity:
≥98%
Molecular Weight:
301.69
Formula :
C10H12ClN5O4
Physical state:
Solid
solubility :
Soluble in water (25 mM), DMSO (100 mM), and methanol (25 mg/ml).
Shipping Condition :
Store at 4° C
Melting point:
238.77° C (Predicted)
SMILES:
C1=NC2=C(N1[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O)N=C(N=C2N)Cl
References:
:2-Chloroadenosine, a preferential agonist of adenosine A1 receptors, enhances the anticonvulsant activity of carbamazepine and clonazepam in mice. | Borowicz, KK., et al. 2002. Eur Neuropsychopharmacol. 12: 173-9. PMID: 11872335STRONG INHIBITION BY 2-CHLOROADENOSINE OF THE AGGREGATION OF BLOOD PLATELETS BY ADENOSINE DIPHOSPHATE.Buy2322869-99-6 | BORN, GV. 1964. Nature. 202: 95-6. PMID: 14166734Mechanism of 2-chloroadenosine toxicity to PC3 cell line. | Minelli, A., et al. 2006. Prostate. 66: 1425-36. PMID: 167419212-Chloroadenosine attenuates NMDA, kainate, and quisqualate toxicity.Bromo-PEG2-C2-acid Data Sheet | Finn, SF., et al. 1991. Neurosci Lett. 126: 191-4. PMID: 19229332-Chloroadenosine decreases long-term potentiation in the hippocampal CA1 area of the rat. | de Mendonça, A. and Ribeiro, JA. 1990. Neurosci Lett. 118: 107-11. PMID: 22594602-chloroadenosine attenuates kainic acid-induced toxicity within the rat straitum: relationship to release of glutamate and Ca2+ influx.PMID:33601927 | Arvin, B., et al. 1989. Br J Pharmacol. 98: 225-35. PMID: 2804547An activator of protein kinase C (phorbol-12-myristate-13-acetate) augments 2-chloroadenosine-elicited accumulation of cyclic AMP in guinea pig cerebral cortical particulate preparations. | Hollingsworth, EB., et al. 1985. FEBS Lett. 184: 339-42. PMID: 2987034An adenosine analogue, 2-chloroadenosine, protects against long term development of ischaemic cell loss in the rat hippocampus. | Evans, MC., et al. 1987. Neurosci Lett. 83: 287-92. PMID: 3441311The adenosine agonist 2-chloroadenosine inhibits the induction of long-term potentiation of the perforant path. | Dolphin, AC. 1983. Neurosci Lett. 39: 83-9. PMID: 63141942-chloroadenosine stimulates granule exocytosis from mouse natural killer cells: evidence for signal transduction through a novel extracellular receptor. | Williams, BA., et al. 1997. Exp Cell Res. 233: 187-97. PMID: 9184087Intra-amygdala infusion of 2-chloroadenosine suppresses amygdala-kindled seizures. | Pourgholami, MH., et al. 1997. Brain Res. 775: 37-42. PMID: 9439826