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THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 288, NO. 36, pp. 25749 ?5759, September 6, 2013 ?2013 by The American Society for Biochemistry and Molecular Biology, Inc. Published in the U.S.A.IruO Is often a Reductase for Heme Degradation by IsdI and IsdG Proteins in Staphylococcus aureus*Received for publication, March 20, 2013, and in revised form, July 22, 2013 Published, JBC Papers in Press, July 26, 2013, DOI ten.1074/jbc.M113.Slade A. Loutet1, Marek J. Kobylarz, Crystal H. T. Chau, and Michael E. P. Murphy2 In the Depa.