Product Name :
3,4-Dihydroxyphenylacetic acid (CAS 102-32-9)
Synonym :
Homoprotocatechuic acid
Application :
CAS:
102-32-9
Purity:
≥98%
Molecular Weight:
168.15
Formula :
C8H8O4
Physical state:
Solid
solubility :
Soluble in water (50 mg/ml), ether, alcohol, methanol, and DMSO.
Shipping Condition :
Store at room temperature
Melting point:
127-130° C (lit.)
SMILES:
C1=CC(=C(C=C1CC(=O)O)O)O
References:
:Conformational preferences of 3,4-dihydroxyphenylacetic acid (DOPAC). | Lopes Jesus, AJ., et al. 2015. Spectrochim Acta A Mol Biomol Spectrosc. 140: 54-64. PMID: 255893873,4-Dihydroxyphenylacetic acid is a predominant biologically-active catabolite of quercetin glycosides. | Tang, Y., et al. 2016. Food Res Int. 89: 716-723. PMID: 284609703,4-Dihydroxyphenylacetic acid is a potential aldehyde dehydrogenase inducer in murine hepatoma Hepa1c1c7 cells. | Liu, Y., et al. 2017. Biosci Biotechnol Biochem. 81: 1978-1983. PMID: 28828965Two flavonoid metabolites, 3,4-dihydroxyphenylacetic acid and 4-methylcatechol, relax arteries ex vivo and decrease blood pressure in vivo. | Pourová, J., et al. 2018. Vascul Pharmacol. 111: 36-43. PMID: 30118763Efficient biosynthesis of 3, 4-dihydroxyphenylacetic acid in Escherichia coli. | Li, X., et al. 2019. J Biotechnol. 294: 14-18. PMID: 30771441Single dose pharmacokinetics of intravenous 3,4-dihydroxyphenylacetic acid and 3-hydroxyphenylacetic acid in rats. | Zabela, V., et al. 2020. Fitoterapia. 142: 104526. PMID: 32097685ZIF-67 as a Template Generating and Tuning ′Raisin Pudding′-Type Nanozymes with Multiple Enzyme-like Activities: Toward Online Electrochemical Detection of 3,4-Dihydroxyphenylacetic Acid in Living Brains. | Liu, J., et al. 2020. ACS Appl Mater Interfaces. 12: 29631-29640. PMID: 32476405The Microbiota-Derived Metabolite of Quercetin, 3,4-Dihydroxyphenylacetic Acid Prevents Malignant Transformation and Mitochondrial Dysfunction Induced by Hemin in Colon Cancer and Normal Colon Epithelia Cell Lines. | Catalán, M., et al. 2020. Molecules. 25: PMID: 32927689In vitro inhibition of glutathione-S-transferase by dopamine and its metabolites, 3,4-dihydroxyphenylacetaldehyde and 3,4-dihydroxyphenylacetic acid. | Crawford, RA., et al. 2021. Neurotoxicology. 86: 85-93. PMID: 34314733Cranberry Proanthocyanidin and Its Microbial Metabolite 3,4-Dihydroxyphenylacetic Acid, but Not 3-(4-Hydroxyphenyl)-Propionic Acid, Partially Reverse Pro-Inflammatory microRNA Responses in Human Intestinal Epithelial Cells. | Lofft, Z., et al. 2022. Mol Nutr Food Res.2410559-72-5 web 66: e2100853.32779-36-5 Safety Information PMID: 35112478Ethanol concentration induces production of 3,4-dihydroxyphenylacetic acid and homovanillic acid in mouse brain through activation of monoamine oxidase pathway.PMID:33557965 | Jamal, M., et al. 2022. Neurosci Lett. 782: 136689. PMID: 355986943,4-Dihydroxyphenylethanol and 3,4-dihydroxyphenylacetic acid affect the aggregation process of E46K variant of alpha -synuclein at different extent: Insights into the interplay between protein dynamics and catechol effect. | Fongaro, B., et al. 2022. Protein Sci. 31: e4356. PMID: 357627143,4-Dihydroxyphenylacetic acid ameliorates gut barrier dysfunction via regulation of MAPK-MLCK pathway in type 2 diabetes mice. | Liu, M., et al. 2022. Life Sci. 305: 120742. PMID: 35777584